Dr. Rachel Green, PhD
Dr. Rachel Green is a professor in the Department of Molecular Biology and Genetics at The Johns Hopkins School of Medicine. She received her PhD in 1993 in the laboratory of Dr. Jack Szostak at Harvard University. Dr. Green then continued her work as a postdoctoral fellow in the laboratory of Dr. Harry Noller at UC Santa Cruz. In 1998, she began lab as an Assistant Professor in the Department of Molecular Biology and Genetics at John Hopkins School of Medicine and was promoted to full professorship in 2007. Her work has been supported by the prestigious Howard Hughes Medical Institute since 2000.
The ribosome is a complex molecular machine that translates the genetic code into functional polypeptides. Work in the Green lab focuses on understanding how the ribosome functions at a molecular level and how the core functions of the ribosome are critical to cellular homeostasis. Their work ranges from ribosome rescue and quality control mechanisms, to ribosome homeostasis, to cellular stress responses and the central role of the ribosome in coordinating them. The Green lab use a wide range of genetic, genomic, and biochemical approaches to explore this biology in bacterial, yeast, and now primarily mammalian systems. Much ongoing work is focused on the central role played by colliding ribosomes in activating cellular signaling pathways such as the integrated stress response (ISR) and the MAPK stress activated pathways.